Cefixime + Ornidazole Tablets

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Therapeutic Indication

Mixed bacterial and protozoal infections
Gastrointestinal infections
Respiratory tract infections
Urinary tract infections
Gynecological infections
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Cefixime + Ornidazole

Tablet

Cefixime Trihydrate is an orally active antibiotic with similar antibacterial spectrum and resistance to β- lactamase as third generation cephalosporins. It inhibits an enzyme transpeptidase which is responsible for bacterial cell walls synthesis.
Ornidazole is a drug that cures some protozoan infections and prophylaxis of anaerobic bacterial infections.It is an antimicrobial agent for the treatment of infections due to trichomonads, amoebae, Giardia lamblia and anaerobic bacteria.

Speciality Internal Medicine | Gastroenterology | Infectious Diseases
Tags Antibiotic | Antiprotozoal | Mixed Infections | GI Infections
Strength
  • Cefixime 200 mg
  • Ornidazole 500 mg
Packing Size
  • 10 Tablets

Check all Tablets Range

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Mechanism

Cefixime is an orally active 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefixime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefixime. It is highly active against enterobacteriaceae, Haemophilus influenzae, Streptococcus pyogens & Streptococcus pneumonia &many beta lactamase producing bacteria.
Ornidazole is a nitro imidazole which has broad spectrum cidal activity against Protozoa and some anaerobic bacteria. Its selective toxicity to anaerobic microbes involves

  • Drug enters the cell by diffusion.
  • Nitro group of drug is reduced by redox proteins present only in anaerobic organisms to reactive nitro radical which excerts cytotoxic action by damaging DNA and other critical biomolecules.
  • DNA helix destabilization &strand breakage has been observed.

Pharmacokinetics

  • Absorption: Cefixime ~40–50% oral bioavailability; Ornidazole rapidly absorbed.
  • Distribution: Both widely distributed in body tissues and fluids.
  • Metabolism: Cefixime minimally metabolized; Ornidazole metabolized in liver.
  • Excretion: Cefixime via urine and feces; Ornidazole via urine.
  • Half-life: Cefixime ~3–4 hours; Ornidazole ~12–14 hours.

Side Effects

  • Diarrhea
  • Nausea, vomiting
  • Abdominal pain
  • Headache, dizziness
  • Skin rash (rare)

Contraindication

  • Hypersensitivity to cephalosporins or nitroimidazoles
  • Severe hepatic impairment
  • Pregnancy (especially first trimester)

Interaction

  • Anticoagulants: Cephalosporins may enhance anticoagulant effect.
  • Alcohol: Ornidazole may cause disulfiram-like reaction.
  • Other antibiotics: Avoid concurrent use with bacteriostatic agents.

Warning and Precautions

  • Monitor liver function during prolonged therapy.
  • Use with caution in renal impairment.
  • Avoid alcohol during treatment with Ornidazole.
  • Discontinue if severe allergic reaction occurs.

Dosage

As directed by the Physician.